Structure via PubChem · Public domain (PubChem)
Indeloxazine
Sign in to saveIndeloxazine (INN; trade names Elen and Noin) is an antidepressant and cerebral activator that was marketed in Japan and South Korea by Yamanouchi Pharmaceutical Co., Ltd for the treatment of psychiatric symptoms associated with cerebrovascular diseases, namely depression resulting from stroke, emotional disturbance, and avolition. It was marketed from 1988 to 1998, when it was removed from the market reportedly for lack of effectiveness.
Chemical data
- Formula
- C14H17NO2
- Molecular weight
- 231.29 g/mol
- IUPAC name
- 2-(3H-inden-4-yloxymethyl)morpholine
- SMILES
- C1COC(CN1)COC2=CC=CC3=C2CC=C3
- InChIKey
- MADRVGBADLFHMO-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 30.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
64 papers- Effects of indeloxazine hydrochloride on passive avoidance behavior of senescence-accelerated mice.European journal of pharmacology · 1989
- Indeloxazine augments long-term potentiation in the mossy fiber-CA3 system of guinea pig hippocampal slices.Journal of pharmacobio-dynamics · 1989
- AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain.Neurological research · 2015
- Cerebral activating properties of indeloxazine HCl and its optical isomers.Pharmacology, biochemistry, and behavior · 1993
- Neurochemical and behavioral characterization of potential antidepressant properties of indeloxazine hydrochloride.Neuropharmacology · 1998
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 231.126
Show 4 more facts
- canonical SMILES
- C1COC(CN1)COC2=CC=CC3=C2CC=C3
- chemical formula
- C₁₄H₁₇NO₂
- subject has role
- nootropic
- Commons category
- Indeloxazine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Indeloxazine (INN; trade names Elen and Noin) is an antidepressant and cerebral activator that was marketed in Japan and South Korea by Yamanouchi Pharmaceutical Co., Ltd for the treatment of psychiatric symptoms associated with cerebrovascular diseases, namely depression resulting from stroke, emotional disturbance, and avolition. It was marketed from 1988 to 1998, when it was removed from the market reportedly for lack of effectiveness.
Indeloxazine acts as a serotonin releasing agent, norepinephrine reuptake inhibitor, and NMDA receptor antagonist. It has been found to enhance acetylcholine release in the rat forebrain through activation of the 5-HT4 receptor via its action as a serotonin releasing agent. The drug has been found to possess nootropic, neuroprotective, anticonvulsant, and antidepressant-like effects in animal models.
Excerpted from Wikipedia’s “Indeloxazine” article, available under the CC BY-SA 4.0 licence.