ABCC2
Sign in to saveAlso known as ABC30, CMOAT, DJS, MRP2, cMRP, Multidrug resistance-associated protein 2, ATP binding cassette subfamily C member 2
gene da espécie Homo sapiens
In the Vinony graph
Within Vinony's link graph, ABCC2 is referenced by 98 other articles, and connects out to ion, PubMed and endothelium.
It is catalogued under topics including ATP-binding cassette transporters and Genes on human chromosome 10.
Its subject is documented across 4 Wikipedia language editions.
Gene data
ABCC2- Name
- ATP binding cassette subfamily C member 2
- Type
- protein-coding
- Position
- 99,782,640–99,853,670 (+)
- Aliases
- ABC30, CMOAT, DJS, MRP2, cMRP
- Ensembl
- ENSG00000023839
- RefSeq RNA
- NM_000392.5, XM_006717630.4, XM_006717631.5, XM_011539291.4, XM_017015675.3
- RefSeq protein
- NP_000383.2, XP_006717693.1, XP_006717694.1, XP_011537593.1, XP_016871164.1
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ATP binding cassette subfamily C member 2
- Symbol
- ABCC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:99,782,640-99,853,670
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
2,464 papers- ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer.Clinical and translational medicine · 2024
- ABCC2/Abcc2: a multispecific transporter with dominant excretory functions.Drug metabolism reviews · 2010
- The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs: A meta-analysis.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2017
- ABCC2/Abcc2 transport property in different species and its modulation by heterogeneous factors.Drug metabolism and pharmacokinetics · 2008
- The apical conjugate efflux pump ABCC2 (MRP2).Pflugers Archiv : European journal of physiology · 2007
via PubMed
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 68052
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1244
- chromosome
- human chromosome 10
- genomic end
- 99852594
- genomic start
- 99782640
- cytogenetic location
- 10q24.2
- genetic association
- Dubin-Johnson syndrome
- expressed in
- sural nerve
Sources (7)
via Wikidata · CC0