ADGRG1
Sign in to saveAlso known as BFPP, BPPR, TM7LN4, TM7XN1, GPR56, adhesion G protein-coupled receptor G1
G protein-coupled receptor 56 also known as TM7XN1 is a protein encoded by the ADGRG1 gene. GPR56 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Gene data
ADGRG1- Name
- adhesion G protein-coupled receptor G1
- Type
- protein-coding
- Aliases
- BFPP, BPPR, CDCBM14B, CDCBM15A, GPR56, TM7LN4, TM7XN1
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
via MyGene.info
Gene · Ensembl
adhesion G protein-coupled receptor G1
- Symbol
- ADGRG1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:57,610,652-57,665,580
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4156
- exact match
- identifiers.org/ncbigene/9289
- genomic start
- 57644564
- cytogenetic location
- 16q21
- genomic end
- 57698944
via Wikidata · CC0
~7 min read
Article
6 sectionsContents
- Ligands
- Signaling
- Function
- Clinical significance
- References
- External links
G protein-coupled receptor 56 also known as TM7XN1 is a protein encoded by the ADGRG1 gene. GPR56 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
GPR56 is expressed in liver, muscle, tendon, neural, and cytotoxic lymphoid cells in human as well as in hematopoietic precursor, muscle, and developing neural cells in the mouse. GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development. More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells.
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via Wikidata sitelinks · CC0