ajmaline
Sign in to saveAlso known as 11,12a-dimethanoindolo[3,2-b]quinolizine-8,13-diol, Ajmalin, (+)-Ajmaline, (5AR,6S,8S,10S,11S,11as,12ar,13R)-5-methyl-5a,6,8,9,10,11,11a,12-octahydro-5H-6,10, (5AR,6S,8S,10S,11S,11as,12ar,13R)-5-methyl-5a,6,8,9,10,11,11a,12-octahydro-5H-6,10:11,12a-dimethanoindolo[3,2-b]quinolizine-8,13-diol
Ajmaline (also known by trade names Gilurytmal, Ritmos, and Aritmina) is an alkaloid that is classified as a 1-A antiarrhythmic agent. It is often used to induce arrhythmic contraction in patients suspected of having Brugada syndrome. Individuals suffering from Brugada syndrome will be more susceptible to the arrhythmogenic effects of the drug, and this can be observed on an electrocardiogram as an ST elevation.
Research
1,514 papers- The synthetic chemistry of sarpagine-ajmaline-type alkaloids.The Alkaloids. Chemistry and biology · 2024
- Ajmaline Testing and the Brugada Syndrome.The American journal of cardiology · 2020
- De novo biosynthesis of antiarrhythmic alkaloid ajmaline.Nature communications · 2024
- The ajmaline group of indole alkaloids.The Alkaloids. Chemistry and biology · 2001
- Ajmaline cardiotoxicity.The American journal of cardiology · 1984
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 326.199428
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₀H₂₆N₂O₂
- defined daily dose
- 0.3
- canonical SMILES
- CCC1C2CC3C4C5(CC(C2C5O)N3C1O)C6=CC=CC=C6N4C
- isomeric SMILES
- CC[C@H]1[C@@H]2C[C@H]3[C@H]4[C@@]5(C[C@@H](C2[C@H]5O)N3[C@@H]1O)C6=CC=CC=C6N4C
- Commons category
- Ajmaline
- melting point
- 206
Sources (3)
via Wikidata · CC0
~6 min read
Encyclopedic overview
5 sectionsContents
- Biosynthesis
- Mechanism of action
- Diagnosis of Brugada syndrome
- See also
- References
Ajmaline (also known by trade names Gilurytmal, Ritmos, and Aritmina) is an alkaloid that is classified as a 1-A antiarrhythmic agent. It is often used to induce arrhythmic contraction in patients suspected of having Brugada syndrome. Individuals suffering from Brugada syndrome will be more susceptible to the arrhythmogenic effects of the drug, and this can be observed on an electrocardiogram as an ST elevation.
The compound was first isolated by Salimuzzaman Siddiqui in 1931 from the roots of Rauvolfia serpentina. He named it ajmaline, after Hakim Ajmal Khan, one of the most illustrious practitioners of Unani medicine in South Asia. Ajmaline can be found in most species of the genus Rauvolfia as well as Catharanthus roseus. In addition to Southeast Asia, Rauvolfia species have also been found in tropical regions of India, Africa, South America, and some oceanic islands. Other indole alkaloids found in Rauvolfia include reserpine, ajmalicine, serpentine, corynanthine, and yohimbine. While 86 alkaloids have been discovered throughout Rauvolfia vomitoria, ajmaline is mainly isolated from the stem bark and roots of the plant.
Excerpted from Wikipedia’s “ajmaline” article, available under the CC BY-SA 4.0 licence.