Structure via PubChem · Public domain (PubChem)
tolazamide
Sign in to saveAlso known as tolazolamide, 4-(p-tolylsulfonyl)-1,1-hexamethylenesemicarbazide, 1-(hexahydro-1-azepinyl)-3-p-tolylsulfonylurea, 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea, N-{[(hexahydro-1H-azepin-1-yl)-amino]carbonyl}-4-methylbenzenesulfonamide, N-(p-toluenesulfonyl)-N'-hexamethyleniminourea
Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).
In the Vinony graph
Within Vinony's link graph, tolazamide is referenced by 452 other articles, and connects out to metformin, valproic acid and alogliptin.
Vinony files it under Azepanes, Benzenesulfonylureas and ECHA InfoCard ID from Wikidata.
Its subject is documented across 16 Wikipedia language editions.
Chemical data
- Formula
- C14H21N3O3S
- Molecular weight
- 311.4 g/mol
- IUPAC name
- 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
- SMILES
- CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CCCCCC2
- InChIKey
- OUDSBRTVNLOZBN-UHFFFAOYSA-N
- XLogP
- 1.5
- Polar surface area
- 86.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1966
- Admin. routes
- oral
- Indications
- diabetes mellitus, type 2 diabetes mellitus
via ChEMBL · EBI
Research
230 papers- Tolazamide.2006
- Sulfonylureas.2012
- Tolazamide-induced hepatic dysfunction.The American journal of gastroenterology · 1978
- Tolazamide (Tolinase).Clinical pharmacology and therapeutics · 1969
- Sulfonylureas, First Generation.2012
via PubMed
Wikidata facts
- Subclass of
- sulfonylurea
- Mass
- 311.130363
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₄H₂₁N₃O₃S
- canonical SMILES
- CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CCCCCC2
- World Health Organisation international non-proprietary name
- tolazamide
- defined daily dose
- 0.5
- subject has role
- anti-diabetic medication
- stylized name
- TOLAZamide
- Commons category
- Tolazamide
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- References
- External links
Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).
==Synthesis== 600px|center|
Excerpted from Wikipedia’s “tolazamide” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
Available in 16 languages
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via Wikidata sitelinks · CC0