Structure via PubChem · Public domain (PubChem)
tipepidine
Sign in to saveTipepidine (INN; also known as tipepidine hibenzate (JAN); brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, and Sotal) is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). The drug was discovered in the 1950s, and was developed in Japan in 1959. It is used as the hibenzate and citrate salts.
Chemical data
- Formula
- C15H17NS2
- Molecular weight
- 275.4 g/mol
- IUPAC name
- 3-(dithiophen-2-ylmethylidene)-1-methylpiperidine
- SMILES
- CN1CCCC(=C(C2=CC=CS2)C3=CC=CS3)C1
- InChIKey
- JWIXXNLOKOAAQT-UHFFFAOYSA-N
- XLogP
- 3.7
- Polar surface area
- 59.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- attention deficit hyperactivity disorder, Cough, depressive disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 275.08
Show 3 more facts
- chemical formula
- C₁₅H₁₇NS₂
- canonical SMILES
- CN1CCCC(=C(C2=CC=CS2)C3=CC=CS3)C1
- Commons category
- Tipepidine
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Tipepidine (INN; also known as tipepidine hibenzate (JAN); brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, and Sotal) is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). The drug was discovered in the 1950s, and was developed in Japan in 1959. It is used as the hibenzate and citrate salts.
The usual dose is 20 mg every 4–6 hours. Possible side effects of tipepidine, especially in overdose, may include drowsiness, vertigo, delirium, disorientation, loss of consciousness, and confusion.
Excerpted from Wikipedia’s “tipepidine” article, available under the CC BY-SA 4.0 licence.
Available in 6 languages
via Wikidata sitelinks · CC0