aleglitazar

Also known as R-1439, Ro-0728804

Aleglitazar is a peroxisome proliferator-activated receptor agonist (hence a PPAR modulator) with affinity to PPARα and PPARγ, which was under development by Hoffmann–La Roche for the treatment of type II diabetes. It is no longer in phase III clinical trials.

Chemical data

Formula: C24H23NO5S
Molecular weight: 437.5 g/mol
IUPAC name: (2S)-2-methoxy-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]propanoic acid
SMILES: CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=C4C=CSC4=C(C=C3)C[C@@H](C(=O)O)OC
InChIKey: DAYKLWSKQJBGCS-NRFANRHFSA-N
XLogP: 5.1
Polar surface area: 110 Å²
H-bond donors: 1
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: type 2 diabetes mellitus

via ChEMBL · EBI

Wikidata facts

Subclass of: carboxylic acid
Mass: 437.13

Show 3 more facts

chemical formula: C₂₄H₂₃NO₅S
isomeric SMILES: CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=C4C=CSC4=C(C=C3)C[C@@H](C(=O)O)OC
canonical SMILES: CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=C4C=CSC4=C(C=C3)CC(C(=O)O)OC

Sources (2)

via Wikidata · CC0

~1 min read

Encyclopedic overview

1 sections

Contents

References

{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477246742 | ImageFile = Aleglitazar.svg | ImageClass = skin-invert-image | ImageSize = 200px | PIN = (2S)-2-Methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid | OtherNames = Ro-0728804, R-1439 |Section1= |Section2= |Section3= }}

Excerpted from Wikipedia’s “aleglitazar” article, available under the CC BY-SA 4.0 licence.

Available in 9 languages

via Wikidata sitelinks · CC0