buformin
Sign in to saveBuformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed by German pharmaceutical company Grünenthal as Silubin.
Chemical data
- Formula
- C6H15N5
- Molecular weight
- 157.22 g/mol
- IUPAC name
- 2-butyl-1-(diaminomethylidene)guanidine
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- +157.133
Show 2 more facts
- P366
- medication
via Wikidata · CC0
Article
11 sectionsContents
- Chemistry and animal toxicology
- Mechanism of action
- Pharmacokinetics
- Dosage
- Side effects and contraindications
- Toxicity
- Anticancer properties
- Antiviral properties
- History
- Synthesis
- References
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed by German pharmaceutical company Grünenthal as Silubin.
==Chemistry and animal toxicology== Buformin hydrochloride is a fine, white to slightly yellow, crystalline, odorless powder, with a weakly acidic bitter taste. Its melting point is 174 to 177 °C, it is a strong base, and is freely soluble in water, methanol and ethanol, but insoluble in chloroform and ether. Toxicity: guinea pig LD50 subcutaneous 18 mg/kg; mouse LD50 intraperitoneal 140 mg/kg and 300 mg/kg oral. The log octanol-water partition coefficient (log P) is -1.20E+00; its water solubility is 7.46E+05 mg/L at 25 °C. Vapor pressure is 1.64E-04 mm Hg at 25 °C (EST); Henry's law constant is 8.14E-16 atm-m3/mole at 25 °C (EST). Its Atmospheric -OH rate constant is 1.60E-10 cm3/molecule-sec at 25 °C.