alteplase
Sign in to saveAlteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. Alteplase is given by injection into a vein or artery. Alteplase is the same as the normal human plasminogen activator produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells
Key facts
- Drug.tradename
- Activase, others
- Drug.MedlinePlus
- a625001
- Drug.DailyMedID
- Alteplase
- Drug.pregnancy_AU
- B1
- Drug.routes_of_administration
- Intravenous
- Drug.class
- Tissue plasminogen activator
- Drug.ATC_prefix
- B01
- Drug.ATC_suffix
- AD02
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.CAS_number
- 105857-23-6
- Drug.DrugBank
- DB00009
- Drug.ChemSpiderID
- none
- Drug.UNII
- 1RXS4UE564
- Drug.KEGG
- D02837
- Drug.synonyms
- t-PA, rt-PA
via Wikipedia infobox
Article
15 sectionsContents
- Medical uses
- Ischemic stroke
- Pulmonary embolism
- Blocked catheters
- Contraindications
- Adverse effects
- Mechanism of action
- Regulation and inhibition
- History
- Society and culture
- Legal status
- Economics
- Brand names
- Controversies
- References
Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. Alteplase is given by injection into a vein or artery. Alteplase is the same as the normal human plasminogen activator produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells (CHO). Alteplase causes the breakdown of a clot by inducing fibrinolysis.
It is on the World Health Organization's List of Essential Medicines.
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Antithrombotic enzymesChemicals that do not have a ChemSpider ID assignedDrugs developed by Boehringer IngelheimDrugs developed by GenentechDrugs developed by Hoffmann-La RocheDrugs with non-standard legal statusFibrinolytic enzymesInfobox drug articles without a structure imageOphthalmology drugsWorld Health Organization essential medicines