alteplase
Sign in to saveAlso known as Tnkase, RT-PA, Retavase, Activase, t-plasminogen activator, Tissue-type plasminogen activator precursor, tPA, t-PA
Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. Alteplase is given by injection into a vein or artery. Alteplase is the same as the normal human plasminogen activator produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells
Key facts
- Drug.tradename
- Activase, others
- Drug.MedlinePlus
- a625001
- Drug.DailyMedID
- Alteplase
- Drug.pregnancy_AU
- B1
- Drug.routes_of_administration
- Intravenous
- Drug.class
- Tissue plasminogen activator
- Drug.ATC_prefix
- B01
- Drug.ATC_suffix
- AD02
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.CAS_number
- 105857-23-6
- Drug.DrugBank
- DB00009
- Drug.ChemSpiderID
- none
- Drug.UNII
- 1RXS4UE564
- Drug.KEGG
- D02837
- Drug.synonyms
- t-PA, rt-PA
via Wikipedia infobox
~8 min read
Encyclopedic overview
15 sectionsContents
- Medical uses
- Ischemic stroke
- Pulmonary embolism
- Blocked catheters
- Contraindications
- Adverse effects
- Mechanism of action
- Regulation and inhibition
- History
- Society and culture
- Legal status
- Economics
- Brand names
- Controversies
- References
Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. Alteplase is given by injection into a vein or artery. Alteplase is the same as the normal human plasminogen activator produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells (CHO). Alteplase causes the breakdown of a clot by inducing fibrinolysis.
It is on the World Health Organization's List of Essential Medicines.
Excerpted from Wikipedia’s “alteplase” article, available under the CC BY-SA 4.0 licence.