altretamine

Also known as Hexalen®, 2,4,6-tris(dimethylamino)-1,3,5-triazine, HMM, 2,4,6-tris(dimethylamino)-s-triazine, Altretaminum, Hexamethylmelamine, Altretamina, Altrétamine

Altretamine (trade name Hexalen), also called hexamethylmelamine, is an antineoplastic agent. It was approved by the U.S. FDA in 1990.

Chemical data

Formula: C9H18N6
Molecular weight: 210.28 g/mol
IUPAC name: 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine
SMILES: CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C
InChIKey: UUVWYPNAQBNQJQ-UHFFFAOYSA-N
XLogP: 2.7
Polar surface area: 48.4 Å²
H-bond donors: 0
H-bond acceptors: 6
Formal charge: 0

via PubChem

Wikidata facts

Mass: 210.159295

Show 4 more facts

chemical formula: C₉H₁₈N₆
canonical SMILES: CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C
World Health Organisation international non-proprietary name: altretamine
Commons category: Altretamine

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Article

6 sections

Contents

Uses
Mechanism
Side effects
Interactions
See also
References

Altretamine (trade name Hexalen), also called hexamethylmelamine, is an antineoplastic agent. It was approved by the U.S. FDA in 1990.

== Uses == It is indicated for use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with cisplatin and/or alkylating agent-based combination.