Amyloid beta precursor protein

Protein · UniProt

Amyloid-beta precursor protein

Gene

APP

Organism

Homo sapiens (Human)

Length

770 aa

Molecular mass

86,943 Da

Evidence

1: Evidence at protein level

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity …

• PHASE2RECRUITING
  Open-label Extension Study in Participants With Early Alzheimer's DiseaseGlaxoSmithKline · NCT07105709
• PHASE1COMPLETED
  Safety, Pharmacokinetics and Pharmacodynamics Study of Treatment With CHF 5074 in Healthy Young Male SubjectsCERESPIR · NCT00954252
• RECRUITING
  Study on Multimodal Imaging and Molecular Imaging Techniques in Degenerative DementiaRuijin Hospital · NCT06534658
• COMPLETED
  Detecting an MCI and Amyloid Digital Neuro Signature(DNS) Using Altoida's Multimodal Digital Biomarkers.Altoida · NCT06223438
• PHASE2COMPLETED
  The Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After StrokeChang Gung Memorial Hospital · NCT04588649
• PHASE1COMPLETED
  Neurogenetic Pharmaceuticals (NGP) 555 in Healthy Volunteers (14 Day Multiple Ascending Dose)NeuroGenetic Pharmaceuticals Inc · NCT02537938

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

via Wikidata · CC0