Amyloid beta precursor protein
Sign in to saveAlso known as amyloid precursor protein, beta-amyloid peptide, amyloid-beta precursor protein, ABPP, PN-II, alzheimer disease amyloid protein, testicular tissue protein Li 2, APP
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, Amyloid beta precursor protein is referenced by 191 other articles, and connects out to PubMed, base pair and cell differentiation.
It sits within the topics Alzheimer's disease, Amyloidosis and Genes on human chromosome 21.
Its subject is documented across 20 Wikipedia language editions.
Protein · UniProt
Amyloid-beta precursor protein
- Gene
- APP
- Organism
- Homo sapiens (Human)
- Length
- 770 aa
- Molecular mass
- 86,943 Da
- Evidence
- 1: Evidence at protein level
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity …
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
4,356 registered- PHASE2RECRUITINGOpen-label Extension Study in Participants With Early Alzheimer's DiseaseGlaxoSmithKline · NCT07105709
- PHASE1COMPLETEDSafety, Pharmacokinetics and Pharmacodynamics Study of Treatment With CHF 5074 in Healthy Young Male SubjectsCERESPIR · NCT00954252
- RECRUITINGStudy on Multimodal Imaging and Molecular Imaging Techniques in Degenerative DementiaRuijin Hospital · NCT06534658
- COMPLETEDDetecting an MCI and Amyloid Digital Neuro Signature(DNS) Using Altoida's Multimodal Digital Biomarkers.Altoida · NCT06223438
- PHASE2COMPLETEDThe Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After StrokeChang Gung Memorial Hospital · NCT04588649
- PHASE1COMPLETEDNeurogenetic Pharmaceuticals (NGP) 555 in Healthy Volunteers (14 Day Multiple Ascending Dose)NeuroGenetic Pharmaceuticals Inc · NCT02537938
Wikidata facts
- Instance of
- protein
Show 5 more facts
- exact match
- purl.uniprot.org/uniprot/P05067
- found in taxon
- Homo sapiens
- cell component
- synaptic vesicle
- Commons category
- Amyloid precursor protein
- physically interacts with
- aducanumab
via Wikidata · CC0