colestipol

Also known as Epichlorohydrin-tetraethylenepentamine polymer, Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane, Colestipolum

Colestipol (trade names Colestid, Cholestabyl) is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein (LDL). It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.

Chemical data

Formula: C11H28ClN5O
Molecular weight: 281.83 g/mol
IUPAC name: N'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;2-(chloromethyl)oxirane
SMILES: C1C(O1)CCl.C(CNCCNCCNCCN)N
InChIKey: GMRWGQCZJGVHKL-UHFFFAOYSA-N
Polar surface area: 101 Å²
H-bond donors: 5
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Unknown

via ChEMBL · EBI

Research

568 papers

Colestipol.2006
Colestipol.2012
Colestipol.2026
Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia.Drugs · 1980
Colestipol and probucol: treatment of primary and familial hypercholesterolemia and amelioration of atherosclerosis.Annals of internal medicine · 1982

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 281.198238
Has use: medication

Show 4 more facts

chemical formula: C₁₁H₂₈ClN₅O
canonical SMILES: C1C(O1)CCl.C(CNCCNCCNCCN)N
defined daily dose: 20
NCI Thesaurus ID: C81540

Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

5 sections

Contents

Side effects
Interactions
Contraindications
Chemistry
Notes and references

Like cholestyramine, colestipol works in the gut by trapping bile acids and preventing them from being reabsorbed. This leads to decreased enterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.

Excerpted from Wikipedia’s “colestipol” article, available under the CC BY-SA 4.0 licence.