etofibrate

Chemical data

Formula

C18H18ClNO5

Molecular weight

363.8 g/mol

IUPAC name

2-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxyethyl pyridine-3-carboxylate

SMILES

CC(C)(C(=O)OCCOC(=O)C1=CN=CC=C1)OC2=CC=C(C=C2)Cl

InChIKey

XXRVYAFBUDSLJX-UHFFFAOYSA-N

XLogP

3.5

Polar surface area

74.7 Ų

H-bond donors

0

H-bond acceptors

6

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Phase 2

Molecule type

Small molecule

Indications

cardiovascular disease

via ChEMBL · EBI

• Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2001
• Studies with etofibrate in the rat. Part I: Effects on glycerol, free fatty acid and triacylglycerol metabolism.Biochimica et biophysica acta · 1988
• [Efficacy and safety of etofibrate in patients with non-proliferative diabetic retinopathy].Klinische Monatsblatter fur Augenheilkunde · 2009
• Confirmation of efficacy of etofibrate against peripheral atherosclerosis in non-human primates which model human lesion types I-VII.Arzneimittel-Forschung · 1996
• Biliary lipids, lithogenic index and biliary drug concentrations during etofibrate and bezafibrate treatment.European journal of drug metabolism and pharmacokinetics · 1995

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

363.08735

Has use

medication

via Wikidata · CC0