aplidin
Sign in to saveAlso known as Dehydrodidemnin B, plitidepsina, Plitidepsin, plitidepsium, plitidepsine
Plitidepsin, also known as dehydrodidemnin B and sold under the brand name Aplidin, is a chemical compound extracted from the ascidian Aplidium albicans.
Research
220 papers- Aplidin PharmaMar.IDrugs : the investigational drugs journal · 2003
- Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts.Oncotarget · 2019
- Population pharmacokinetics meta-analysis of plitidepsin (Aplidin) in cancer subjects.Cancer chemotherapy and pharmacology · 2009
- Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo.Cancer research · 2008
- Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation.Cell death and differentiation · 2006
via PubMed
~3 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Pharmacological activity
- Society and culture
- Legal status
- References
- Further reading
{{Chembox | Watchedfields = changed | verifiedrevid = 434307328 | ImageFile = Aplidine.svg | ImageSize = 200 | SystematicName = (2S)-N-[(1R)-1-({(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-10-[(2S)-Butan-2-yl]-11-hydroxy-3-[(4-methoxyphenyl)methyl]-2,6,17-trimethyl-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxo-15-(propan-2-yl)docosahydro-15H-pyrrolo[2,1-d][10,19,1,4,7,14]dioxatetraazacyclotricosin-7-yl}carbamoyl)-3-methylbutyl]-N-methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide | OtherNames = Aplidine; Aplidin, dehydrodidemnin B; Aplidin; N-[1-(1,2-Dioxopropyl)-L-prolyl]didemnin A |Section1= |Section2= | Section6 = | Section7 = }}
Plitidepsin, also known as dehydrodidemnin B and sold under the brand name Aplidin, is a chemical compound extracted from the ascidian Aplidium albicans.
Excerpted from Wikipedia’s “aplidin” article, available under the CC BY-SA 4.0 licence.