verteporfin
Sign in to saveAlso known as BPD952, CL-318952
Verteporfin (trade name Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 689 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 470629762
- Drug.IUPAC_name
- 3-[(23S,24R)-14-ethenyl-5-(3-methoxy-3-oxopropyl)-22,23-bis(methoxycarbonyl)-4,10,15,24-tetramethyl-25,26,27,28-tetraazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1,3,5,7,9,11(27),12,14,16,18(25),19,21-dodecaen-9-yl]propanoic acid
- Drug.image
- Verteporfin.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Visudyne
- Drug.MedlinePlus
- a607060
- Drug.pregnancy_US
- C
- Drug.licence_EU
- yes
- Drug.legal_US
- Rx-only
- Drug.routes_of_administration
- Intravenous
- Drug.CAS_number
- 129497–78–5
- Drug.ATC_prefix
- S01
- Drug.ATC_suffix
- LA01
- Drug.PubChem
- 5362420
- Drug.DrugBank
- DB00460
- Drug.ChemSpiderID
- 21106402
- Drug.UNII
- 0X9PA28K43
via Wikipedia infobox
Research
2,794 papers- Verteporfin.Drugs & aging · 2000
- Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor verteporfin in preclinical glioblastoma models.Neuro-oncology · 2022
- Verteporfin for age-related macular degeneration.The Annals of pharmacotherapy · 2001
- Verteporfin ocular photodynamic therapy.Expert opinion on pharmacotherapy · 2004
- Repurposing the drug verteporfin as anti-neoplastic therapy for glioblastoma.Neuro-oncology · 2022
via PubMed
Wikidata facts
- Mass
- 2875.2
Show 3 more facts
- World Health Organisation international non-proprietary name
- verteporfin
- NCI Thesaurus ID
- C1014
- chemical formula
- C₁₆₄H₁₆₈N₁₆O₃₂
via Wikidata · CC0
~3 min read
Article
9 sectionsContents
- Administration
- Contraindications
- Side effects
- Light-activated cytotoxicity
- Interactions
- Shortages
- Off-label use
- References
- External links
Verteporfin (trade name Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 689 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Verteporfin is also used off-label for the treatment of central serous retinopathy.
Available in 13 languages
via Wikidata sitelinks · CC0