ARAF
Sign in to saveAlso known as A-Raf proto-oncogene, serine/threonine kinase, A-RAF, ARAF1, PKS2, RAFA1, Serine/threonine-protein kinase A-Raf
Serine/threonine-protein kinase A-Raf, or simply A-Raf, is an enzyme that in humans is encoded by the ARAF gene. It belongs to the Raf kinase family of serine/threonine-specific protein kinases, which also includes Raf-1 and B-Raf. A-Raf is involved in the MAPK/ERK pathway, where it contributes to cell signaling processes that regulate proliferation, survival, and differentiation. Compared to Raf-1 and B-Raf, A-Raf is less well studied and exhibits distinct structural and regulatory features, including low kinase activity and alternative splicing in cancer. In addition to its role in MAPK sign
Gene data
ARAF- Name
- A-Raf proto-oncogene, serine/threonine kinase
- Type
- protein-coding
- Chromosome
- X
- Position
- 47,561,043–47,571,921 (+)
- Aliases
- A-RAF, ARAF1, PKS2, RAFA1
- Ensembl
- ENSG00000078061
- RefSeq RNA
- NM_001256196.2, NM_001256197.2, NM_001654.5
- RefSeq protein
- NP_001243125.1, NP_001243126.1, NP_001645.1
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
A-Raf proto-oncogene, serine/threonine kinase
- Symbol
- ARAF
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:47,561,043-47,571,921
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ARAF PDB 1wxm.png
Show 7 more facts
- HomoloGene ID
- 1249
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/369
- genomic start
- 47561205
- genomic end
- 47571908
- chromosome
- human X chromosome
- cytogenetic location
- Xp11.3
via Wikidata · CC0
Article · 日本語
セリン/トレオニンタンパク質キナーゼ A-Raf（セリン/トレオニン-タンパクしつキナーゼ・エイラフ、英: Serine/threonine-protein kinase A-Raf）あるいは単純にA-Rafは、ヒトARAF遺伝子にコードされている酵素である。A-RafはのRafキナーゼファミリーのメンバーである。
Abstract from DBpedia / Wikipedia · CC BY-SA