baicalein
Sign in to saveAlso known as 5,6,7-trihydroxyflavone
Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also a constituent of Oroxylum indicum (Indian trumpetflower) and thyme. It is the aglycone of baicalin.
Key facts
- Drug.drug_name
- Baicalein
- Drug.image
- Baicalein.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Baicalein-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.CAS_number
- 491-67-8
- Drug.PubChem
- 5281605
- Drug.IUPHAR_ligand
- 5144
- Drug.ChemSpiderID
- 4444924
- Drug.UNII
- 49QAH60606
- Drug.KEGG
- C10023
- Drug.ChEBI
- 2979
- Drug.ChEMBL
- 8260
- Drug.synonyms
- Biacalein; Noroxylin
- Drug.IUPAC_name
- 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
- Drug.C
- 15
- Drug.H
- 10
- Drug.O
- 5
via Wikipedia infobox
Research
3,349 papers- Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s.Acta pharmacologica Sinica · 2022
- Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer.Journal of advanced research · 2025
- Baicalein increases cisplatin sensitivity of A549 lung adenocarcinoma cells via PI3K/Akt/NF-κB pathway.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017
- Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis.Acta pharmacologica Sinica · 2024
- Baicalein alleviates cisplatin-induced acute kidney injury by inhibiting ALOX12-dependent ferroptosis.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2024
via PubMed
Wikidata facts
- Mass
- 270.053
Show 4 more facts
- chemical formula
- C₁₅H₁₀O₅
- canonical SMILES
- C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)O)O)O
- melting point
- 269
- Commons category
- Baicalein
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Article
3 sectionsContents
- Pharmacology
- See also
- References
Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also a constituent of Oroxylum indicum (Indian trumpetflower) and thyme. It is the aglycone of baicalin.
==Pharmacology== Baicalein, along with its glucuronide baicalin, is a positive allosteric modulator of the benzodiazepine site and a non-benzodiazepine site of the GABAA receptor, but with an affinity over 250× lower than diazepam. It displays subtype selectivity for α2 and α3 subunit-containing GABAA receptors.
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