BCCIP

Also known as TOK-1, TOK1, BRCA2 and CDKN1A interacting protein

BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.

In the Vinony graph

Within Vinony's link graph, BCCIP is referenced by 4 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 10.

Its subject is documented across 5 Wikipedia language editions.

Gene data

BCCIP

Name: BRCA2 and CDKN1A interacting protein
Type: protein-coding
Position: 125,823,523–125,854,471 (+)
Aliases: TOK-1, TOK1
Ensembl: ENSG00000107949
RefSeq RNA: NM_016567.4, NM_078468.3, NM_078469.3
RefSeq protein: NP_057651.1, NP_510868.1, NP_510869.1

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

BRCA2 and CDKN1A interacting protein

Symbol: BCCIP
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:125,823,523-125,854,471
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 41629
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/56647
chromosome: human chromosome 10
genomic start: 127512115
genomic end: 127542264
cytogenetic location: 10q26.2
expressed in: rectum

Sources (4)

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Encyclopedic overview

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Contents

Interactions
References
External links
Further reading

BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.

This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.

Excerpted from Wikipedia’s “BCCIP” article, available under the CC BY-SA 4.0 licence.