RCBTB2

Also known as CHC1L, RLG, RCC1 and BTB domain containing protein 2

RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.

Gene data

RCBTB2

Name: RCC1 and BTB domain containing protein 2
Type: protein-coding
Position: 48,488,959–48,536,006 (−)
Aliases: CHC1L, RLG
Ensembl: ENSG00000136161
RefSeq RNA: NM_001268.4, NM_001286830.2, NM_001286831.2, NM_001286832.2, NM_001352424.2
RefSeq protein: NP_001259.1, NP_001273759.1, NP_001273760.1, NP_001273761.1, NP_001339353.1

This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].

Gene Ontology

Molecular function

guanyl-nucleotide exchange factor activity protein binding

Cellular component

acrosomal vesicle cytoplasm

via MyGene.info

Wikidata facts

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HomoloGene ID: 970
exact match: identifiers.org/ncbigene/1102
genomic end: 49107369
genomic start: 48488963
cytogenetic location: 13q14.2

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Further reading

RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.

This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.