benzimidazole
Sign in to saveBenzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound may be viewed as fused rings of the aromatic compounds benzene and imidazole. It is a white solid that appears in form of tabular crystals.
Research
66,404 papers- Benzimidazole and Benzoxazole Derivatives Against Alzheimer's Disease.Chemistry & biodiversity · 2024
- Benzimidazole-Oxadiazole Hybrids-Development in Medicinal Chemistry: An Overview.Chemical biology & drug design · 2024
- Benzimidazole as a Privileged Scaffold in Drug Design and Discovery.Current topics in medicinal chemistry · 2024
- Coumarin-benzimidazole hybrids: A review of developments in medicinal chemistry.European journal of medicinal chemistry · 2022
- Benzimidazole-based protein kinase inhibitors: Current perspectives in targeted cancer therapy.Chemical biology & drug design · 2022
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Article
6 sectionsContents
- Preparation
- Reactions
- Applications
- See also
- References
- Further reading
Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound may be viewed as fused rings of the aromatic compounds benzene and imidazole. It is a white solid that appears in form of tabular crystals.
== Preparation == Benzimidazole was discovered during research on vitamin B12. The benzimidazole nucleus was found to be a stable platform on which drugs could be developed. Benzimidazole is produced by condensation of o-phenylenediamine with formic acid, or the equivalent trimethyl orthoformate: C6H4(NH2)2 + HC(OCH3)3 → C6H4N(NH)CH + 3 CH3OH