Structure via PubChem · Public domain (PubChem)
biperiden
Sign in to saveAlso known as Akineton®, alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanol, alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol, Beperiden, alpha-Bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol, Biperidene, 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol
Biperiden, sold under the brand name Akineton among others, is a medication used to treat Parkinson disease, certain drug-induced movement disorders and Tourette Syndrome. It is not recommended for tardive dyskinesias. It is taken by mouth, injection into a vein, or muscle.
In the Vinony graph
Vinony's link graph records 621 inbound references to biperiden, and connects out to cannabinoids, muscarinic acetylcholine receptor family and muscarinic antagonist.
Vinony files it under 1-Piperidinyl compounds, Antiparkinsonian agents and Cyclopentenes.
Vinony links it to 29 Wikipedia language editions.
Chemical data
- Formula
- C21H29NO
- Molecular weight
- 311.5 g/mol
- IUPAC name
- 1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
- SMILES
- C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O
- InChIKey
- YSXKPIUOCJLQIE-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1959
- Admin. routes
- oral, parenteral
- Indications
- cocaine dependence, anxiety, Dementia, depressive disorder
via ChEMBL · EBI
Research
786 papers- Biperiden.2006
- Biperiden.2012
- Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis.JAMA network open · 2024
- Biperiden-Induced Delirium In A Five-Years Old Child.Current drug safety · 2019
- Biperiden reverses the increase in 50-kHz ultrasonic vocalizations but not the increase in locomotor activity induced by cocaine.Behavioural brain research · 2024
via PubMed
Wikidata facts
- Subclass of
- tertiary alcohol
- Mass
- 311.225
Show 6 more facts
- chemical formula
- C₂₁H₂₉NO
- Commons category
- Biperiden
- World Health Organisation international non-proprietary name
- biperiden
- canonical SMILES
- C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O
- subject has role
- essential medicine
- defined daily dose
- 10
via Wikidata · CC0
~7 min read
Encyclopedic overview
14 sectionsContents
- Medical uses
- Pregnancy and lactation
- Children
- Contraindications
- Side effects
- Interactions
- Overdose
- Pharmacology
- Pharmacodynamics
- Anticholinergic activity
- Other actions
- Pharmacokinetics
- History
- References
Biperiden, sold under the brand name Akineton among others, is a medication used to treat Parkinson disease, certain drug-induced movement disorders and Tourette Syndrome. It is not recommended for tardive dyskinesias. It is taken by mouth, injection into a vein, or muscle.
Common side effects include blurred vision, dry mouth, sleepiness, constipation, and confusion. It should not be used in people with a bowel obstruction or glaucoma. It is unclear if use in pregnancy or breastfeeding is safe. Biperiden is in the anticholinergic family of medication.
Excerpted from Wikipedia’s “biperiden” article, available under the CC BY-SA 4.0 licence.