BMP5

Name

bone morphogenetic protein 5

Type

protein-coding

Position

55,753,619–55,875,601 (−)

Ensembl

ENSG00000112175

RefSeq RNA

NM_001329754.2, NM_001329756.2, NM_021073.4, XM_011514817.4, XM_024446524.2

RefSeq protein

NP_001316683.1, NP_001316685.1, NP_066551.1, XP_011513119.1, XP_024302292.1

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016].

via MyGene.info

Gene · Ensembl

bone morphogenetic protein 5

Symbol

BMP5

Biotype

Protein coding

Organism

Homo sapiens

Location

6:55,753,619-55,875,601

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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