BMP5
Sign in to saveAlso known as entrez:653, bone morphogenetic protein 5
protein-coding gene in the species Homo sapiens
Gene data
BMP5- Name
- bone morphogenetic protein 5
- Type
- protein-coding
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 22412
- exact match
- identifiers.org/ncbigene/653
- genomic end
- 55875590
- genomic start
- 55753653
- cytogenetic location
- 6p12.1
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