SMAD3

Also known as HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.

Gene data

SMAD3

Name: SMAD family member 3
Type: protein-coding
Position: 67,063,763–67,195,173 (+)
Aliases: HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, hMAD-3, hSMAD3, mad3
Ensembl: ENSG00000166949
RefSeq RNA: NM_001145102.2, NM_001145103.2, NM_001145104.2, NM_001407011.1, NM_001407012.1
RefSeq protein: NP_001138574.1, NP_001138575.1, NP_001138576.1, NP_001393940.1, NP_001393941.1

The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, May 2022].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II MAPK cascade osteoblast differentiation ureteric bud development response to hypoxia release of cytochrome c from mitochondria

Molecular function

transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus nuclear inner membrane nucleoplasm

Pathways

FoxO signaling pathway - Homo sapiens (human)Cell cycle - Homo sapiens (human)Endocytosis - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Wnt signaling pathway - Homo sapiens (human)TGF-beta signaling pathway - Homo sapiens (human)Apelin signaling pathway - Homo sapiens (human)Hippo signaling pathway - Homo sapiens (human)Adherens junction - Homo sapiens (human)Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

SMAD family member 3

Symbol: SMAD3
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:67,063,763-67,195,173
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein SMAD3 PDB 1dev.png

Show 5 more facts

HomoloGene ID: 55937
exact match: identifiers.org/ncbigene/4088
genomic end: 67195173
genomic start: 67356101
cytogenetic location: 15q22.33

Sources (7)

via Wikidata · CC0

~13 min read

Article

19 sections

Contents

Gene
Protein
Structure
MH1 domain
MH2 domain
Functions and interactions
TGF-β/SMAD signaling pathway
TGF-β/SMAD3-induced repression
Clinical significance
Diseases
Role in cancer
Prostate
Colorectal
Breast
Kidney
Nomenclature
References
Further reading
External links

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.

SMAD3 is a member of the SMAD family of proteins. It acts as a mediator of the signals initiated by the transforming growth factor beta (TGF-β) superfamily of cytokines, which regulate cell proliferation, differentiation and death. Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development.