GDF10
Sign in to saveAlso known as BMP-3b, BMP3B, growth differentiation factor 10, BIP
Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.
Gene data
GDF10- Name
- growth differentiation factor 10
- Type
- protein-coding
- Position
- 47,300,060–47,313,580 (+)
- Aliases
- BIP, BMP-3b, BMP3B
- Ensembl
- ENSG00000266524
- RefSeq RNA
- NM_004962.5
- RefSeq protein
- NP_004953.1
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016].
Gene Ontology
Biological process
via MyGene.info
Gene · Ensembl
growth differentiation factor 10
- Symbol
- GDF10
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:47,300,060-47,313,580
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.
GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis. GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.
Excerpted from Wikipedia’s “GDF10” article, available under the CC BY-SA 4.0 licence.