Gene data
BRD4- Name
- bromodomain containing 4
- Type
- protein-coding
- Position
- 15,235,519–15,332,547 (−)
- Aliases
- CAP, CDLS6, FSHRG4, HUNK1, HUNKI, MCAP
- Ensembl
- ENSG00000141867
- RefSeq RNA
- NM_001330384.2, NM_001379291.1, NM_001379292.1, NM_014299.3, NM_058243.3
- RefSeq protein
- NP_001317313.1, NP_001366220.1, NP_001366221.1, NP_055114.1, NP_490597.1
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
chromatin remodelingchromatin remodelingregulation of DNA-templated transcriptionregulation of transcription by RNA polymerase IIregulation of transcription by RNA polymerase IIDNA damage responsepositive regulation of G2/M transition of mitotic cell cyclepositive regulation of transcription elongation by RNA polymerase II
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
bromodomain containing 4
- Symbol
- BRD4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:15,235,519-15,332,547
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein BRD4 PDB 2oss.png
Show 8 more facts
- HomoloGene ID
- 137685
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23476
- genomic end
- 15443356
- genomic start
- 15347647
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.12
- expressed in
- vena cava
via Wikidata · CC0