CABLES1

Also known as CABL1, CABLES, HsT2563, IK3-1, Cdk5 and Abl enzyme substrate 1

CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to CABLES1, and connects out to PubMed, human chromosome 18 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 18.

Vinony links it to 6 Wikipedia language editions.

Gene data

CABLES1

Name: Cdk5 and Abl enzyme substrate 1
Type: protein-coding
Position: 23,134,564–23,260,470 (+)
Aliases: CABL1, CABLES, HsT2563, IK3-1
Ensembl: ENSG00000134508
RefSeq RNA: NM_001100619.3, NM_001256438.1, NM_138375.3, NR_023359.2
RefSeq protein: NP_001094089.1, NP_001243367.1, NP_612384.1

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

Gene Ontology

Biological process

nervous system development regulation of cell cycle

Molecular function

protein binding

Cellular component

nucleus cytoplasm cytosol cytosol

Pathways

Hemostasis Cell Cycle Mitotic G1 phase and G1/S transition Cyclin E associated events during G1/S transition G1/S Transition S Phase Cell Cycle, Mitotic Cyclin A:Cdk2-associated events at S phase entry Factors involved in megakaryocyte development and platelet production

via MyGene.info

Gene · Ensembl

Cdk5 and Abl enzyme substrate 1

Symbol: CABLES1
Biotype: Protein coding
Organism: Homo sapiens
Location: 18:23,134,564-23,260,470
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 11097
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/91768
genomic end: 23260470
genomic start: 20714528
chromosome: human chromosome 18
cytogenetic location: 18q11.2
expressed in: cingulate gyrus

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

References
External links
Further reading

CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.

CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or cell differentiation. [supplied by OMIM]. It is a tumor suppressor gene which losing it (by mutations, knockout, knockdown or inactivation) may lead to colorectal cancer CRC.

Excerpted from Wikipedia’s “CABLES1” article, available under the CC BY-SA 4.0 licence.