CABLES1
Sign in to saveAlso known as CABL1, CABLES, HsT2563, IK3-1, Cdk5 and Abl enzyme substrate 1
CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.
Gene data
CABLES1- Name
- Cdk5 and Abl enzyme substrate 1
- Type
- protein-coding
- Aliases
- CABL1, CABLES, HsT2563, IK3-1
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 11097
- exact match
- identifiers.org/ncbigene/91768
- genomic end
- 23260470
- genomic start
- 20714528
- cytogenetic location
- 18q11.2
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CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.
CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or cell differentiation. [supplied by OMIM]. It is a tumor suppressor gene which losing it (by mutations, knockout, knockdown or inactivation) may lead to colorectal cancer CRC.