cannabinoid receptor 1
Sign in to saveAlso known as CNR1, CANN6, central cannabinoid receptor, cannabinoid receptor 1 (brain), Receptor, Cannabinoid, CB1
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, cannabinoid receptor 1 is referenced by 1,188 other articles, and connects out to cannabinoids, cerebellum and PubMed.
It is catalogued under topics including Genes on human chromosome 6 and G protein-coupled receptors.
Its subject is documented across 16 Wikipedia language editions.
Protein · UniProt
Cannabinoid receptor 1
- Gene
- CNR1
- Organism
- Homo sapiens (Human)
- Length
- 472 aa
- Molecular mass
- 52,858 Da
- Evidence
- 1: Evidence at protein level
G protein-coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727, PubMed:35637350). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In th…
Swiss-Prot (reviewed) · via UniProt
Research
1,563 papers- Snapshot of the cannabinoid receptor 1-arrestin complex unravels the biased signaling mechanism.Cell · 2023
- Cannabinoid receptor 1 ligands: Biased signaling mechanisms driving functionally selective drug discovery.Pharmacology & therapeutics · 2025
- Allosteric Modulation of Cannabinoid Receptor 1-Current Challenges and Future Opportunities.International journal of molecular sciences · 2019
- Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation.Cell · 2022
- Cannabinoid Receptor 1 Antagonism Demonstrates High Therapeutic Potential for the Treatment of Primary Sclerosing Cholangitis.Cellular and molecular gastroenterology and hepatology · 2022
via PubMed
Clinical Trials
21 registered- UNKNOWNGenes Polymorphisms and Metabolic Effects of the Second Generation Antipsychotic Drugs in Patients With SchizophreniaXijing Hospital · NCT02964923
- PHASE1COMPLETEDImaging of Cannabinoid Receptors Using New Radioactive TracerNational Institute of Mental Health (NIMH) · NCT00450021
- NAACTIVE_NOT_RECRUITINGCB1R in Synthetic Psychoactive CannabinoidsYale University · NCT03539575
- NARECRUITINGTranslational Study Using Human Abdominal Adipose Tissue Biopsies to Investigate the Role of Cannabinoid Receptor 1 (CB1) in Controlling Endocannabinoid and Adipokine SecretionCentre Hospitalier Universitaire Dijon · NCT04940962
- PHASE1COMPLETEDAntagonistic Interaction CB1-paracetamolUniversity Hospital, Clermont-Ferrand · NCT00750347
- ENROLLING_BY_INVITATIONConcentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle OriginWroclaw Medical University · NCT06405646
Wikidata facts
- Instance of
- protein
Show 2 more facts
- Commons category
- Cannabinoid receptor 1
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0