captopril

Also known as Capoten®, SQ-14225, D-3-mercapto-2-methylpropanoyl-L-proline, D-2-methyl-3-mercaptopropanoyl-L-proline, Captopryl, L-Captopril, (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid, CP

Chemical data

Formula: C9H15NO3S
Molecular weight: 217.29 g/mol
IUPAC name: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O
InChIKey: FAKRSMQSSFJEIM-RQJHMYQMSA-N
XLogP: 0.3
Polar surface area: 58.6 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Research

14,180 papers

Captopril.

~8 min read

Article

11 sections

Contents

Structure–activity relationship
Medical uses
Adverse effects
Overdose
History
Chemical synthesis
Mechanism of action
Pharmacokinetics
See also
References
External links

Captopril, sold under the brand name Capoten among others, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first oral ACE inhibitor found for the treatment of hypertension. It does not cause fatigue as associated with beta-blockers.

Captopril was patented in 1976 and approved for medical use in 1980.