delapril
Sign in to saveDelapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug in some European and Asian countries but not in America. It is taken orally, available in 15 mg and 30 mg tablets.
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 452.231
Show 8 more facts
- chemical formula
- C₂₆H₃₂N₂O₅
- subject has role
- antihypertensive drug
- isomeric SMILES
- CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2
- canonical SMILES
- CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2
- Commons category
- Delapril
- medical condition treated
- arterial hypertension
- defined daily dose
- 30
- physically interacts with
- angiotensin I converting enzyme
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Encyclopedic overview
2 sectionsContents
- Mechanism
- References
Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug in some European and Asian countries but not in America. It is taken orally, available in 15 mg and 30 mg tablets.
== Mechanism == Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.
Excerpted from Wikipedia’s “delapril” article, available under the CC BY-SA 4.0 licence.