Cathepsin A
Sign in to saveAlso known as urinary kininase, beta-galactosidase 2, lysosomal carboxypeptidase A, protective protein cathepsin A, carboxypeptidase C, beta-galactosidase protective protein, PPCA, Carboxypeptidase L
mammalian protein found in Homo sapiens
Protein · UniProt
Lysosomal protective protein
- Gene
- CTSA
- Organism
- Homo sapiens (Human)
- Length
- 480 aa
- Molecular mass
- 54,466 Da
- Evidence
- 1: Evidence at protein level
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity (PubMed:1907282). Also functions as an activator of the sialidase NEU1 (PubMed:37205763). This protein is also a carboxypeptidase and can deamidate tachykinins (PubMed:1694176, PubMed:1756715, PubMed:1907282)
3D-structureAlternative splicingCarboxypeptidaseDirect protein sequencingDisease variantDisulfide bondGlycoproteinHydrolase
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
901 papers- Cathepsin A activity of a parietal thrombus of an abdominal aortic aneurysm.Folia histochemica et cytobiologica · 2011
- Cathepsin A/protective protein: an unusual lysosomal multifunctional protein.Cellular and molecular life sciences : CMLS · 1999
- Update on hereditary, autosomal dominant cathepsin-A-related arteriopathy with strokes and leukoencephalopathy (CARASAL).Acta neurologica Belgica · 2019
- Role of cathepsin A and cathepsin C in the regulation of glycosidase activity.Folia histochemica et cytobiologica · 2012
- Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-Obesity Cyclic Peptide.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
via PubMed
Clinical Trials
9 registered- NOT_YET_RECRUITINGDiagnostic Value of Serum Cathepsin S and Chromogranin A in DKDAssiut University · NCT06069076
- PHASE2COMPLETEDA Study to Examine the Effects of an Experimental Drug on Postmenopausal Osteoporosis (MK-0822-004)Merck Sharp & Dohme LLC · NCT00112437
- PHASE2COMPLETEDSafety and Effectiveness Study of RWJ-445380 Cathepsin-S Inhibitor in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyJohnson & Johnson Pharmaceutical Research & Development, L.L.C. · NCT00425321
- UNKNOWNRegistry GangliosidosesSphinCS Lyso Gemeinnutzige UG (Haftungsbeschrankt) · NCT04624789
- COMPLETEDLymphangioleiomyomatosis, a Study on Cathepsin KUniversity Hospital, Tours · NCT05323370
- COMPLETEDOxidoreductive Balance and Lysosomal Activity in Cancer Patients.Nicolaus Copernicus University · NCT03470857