CD70 molecule
Sign in to saveAlso known as CD27-L, Ki-24 antigen, CD70, surface antigen CD70, tumor necrosis factor ligand 8A, CD27 ligand, tumor necrosis factor ligand superfamily member 7, CD70 antigen
CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is also known as a ligand for CD27.
Research
312 papers- CD70-targeted iPSC-derived CAR-NK cells display potent function against tumors and alloreactive T cells.Cell reports. Medicine · 2025
- CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma.Cancer discovery · 2024
- CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance.Cancer cell · 2023
- CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy.Blood advances · 2024
- Expression of costimulatory molecule CD70 is prognostic in small cell lung cancer.Cancer immunology, immunotherapy : CII · 2025
via PubMed
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Article
8 sectionsContents
- Expression
- Functions
- Clinical significance
- Cancer
- Drug development
- See also
- References
- External links
CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is also known as a ligand for CD27.
== Expression == In physiological condition the expression of CD70 on immune cells is transient and tightly controlled. It is primarily expressed on highly activated T cells and B cells, as well as on NK cells and mature dendritic cells. CD70 expression on T and B cells is stimulated through triggering of T and B cell receptors and can be upregulated by cytokines such as IL-1α, IL-2, IL-12, GM-CSF and TNF-α, while IL-4 and IL-10 can decrease CD70 expression. Expression of CD70 on mDCs and pDCs is induced with Toll-like receptor (TLR) triggering and CD40 ligation. Also, CD70 can be induced on NK cells upon stimulation with IL-15.