CD19
Sign in to saveAlso known as differentiation antigen CD19, B-lymphocyte surface antigen B4, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, Antigens, C19, Antigens, CD19
B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19. In humans, CD19 is expressed in all B lineage cells. Contrary to some early doubts, human plasma cells do express CD19. CD19 plays two major roles in human B cells: on the one hand, it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane; on the other, it works within the CD19/CD21 complex to decrease the threshold for B cell receptor
Protein · UniProt
B-lymphocyte antigen CD19
- Gene
- CD19
- Organism
- Homo sapiens (Human)
- Length
- 556 aa
- Molecular mass
- 61,128 Da
- Evidence
- 1: Evidence at protein level
Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:16672701, PubMed:9317126, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 3 more facts
- found in taxon
- Homo sapiens
- cell component
- membrane raft
- exact match
- purl.uniprot.org/uniprot/P15391
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