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CD1a molecule
Sign in to saveAlso known as CD1A antigen, a polypeptide, hTa1 thymocyte antigen, CD1A, cortical thymocyte antigen CD1A, differentiation antigen CD1-alpha-3, cluster of differentiation 1 A, T-cell surface antigen T6/Leu-6, epidermal dendritic cell marker CD1a
CD1a (Cluster of Differentiation 1a) is a human protein encoded by the gene.
Protein · UniProt
T-cell surface glycoprotein CD1a
- Gene
- CD1A
- Organism
- Homo sapiens (Human)
- Length
- 327 aa
- Molecular mass
- 37,077 Da
- Evidence
- 1: Evidence at protein level
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells
Swiss-Prot (reviewed) · via UniProt
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
CD1a (Cluster of Differentiation 1a) is a human protein encoded by the gene.
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytotic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. Transcript levels of the CD1A gene are upregulated in the lung parenchyma of smokers.
Excerpted from Wikipedia’s “CD1a molecule” article, available under the CC BY-SA 4.0 licence.