CD3E

Name

CD3 epsilon subunit of T-cell receptor complex

Type

protein-coding

Position

118,304,701–118,316,175 (+)

Aliases

CD3epsilon, IMD18, T3E, TCRE

Ensembl

ENSG00000198851

RefSeq RNA

NM_000733.4

RefSeq protein

NP_000724.1

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

CD3 epsilon subunit of T-cell receptor complex

Symbol

CD3E

Biotype

Protein coding

Organism

Homo sapiens

Location

11:118,304,701-118,316,175

Strand

Forward (+)

Assembly

GRCh38