CD3E
Sign in to saveAlso known as IMD18, T3E, TCRE, CD3e molecule, CD3epsilon, CD3 epsilon subunit of T-cell receptor complex
gene umano
In the Vinony graph
Vinony's link graph records 398 inbound references to CD3E, and connects out to PubMed, Ensembl genome database project and CD1.
It sits within the topics Clusters of differentiation and Genes on human chromosome 11.
Vinony links it to 5 Wikipedia language editions.
Gene data
CD3E- Name
- CD3 epsilon subunit of T-cell receptor complex
- Type
- protein-coding
- Position
- 118,304,701–118,316,175 (+)
- Aliases
- CD3epsilon, IMD18, T3E, TCRE
- Ensembl
- ENSG00000198851
- RefSeq RNA
- NM_000733.4
- RefSeq protein
- NP_000724.1
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CD3 epsilon subunit of T-cell receptor complex
- Symbol
- CD3E
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:118,304,701-118,316,175
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CD3E PDB 1xiw.png
Show 7 more facts
- HomoloGene ID
- 586
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/916
- genomic end
- 118186890
- genomic start
- 118304730
- chromosome
- human chromosome 11
- cytogenetic location
- 11q23.3
via Wikidata · CC0