CD63
Sign in to saveAlso known as ocular melanoma-associated antigen, melanoma-associated antigen MLA1, lysosome-associated membrane glycoprotein 3, CD63 antigen (melanoma 1 antigen), OMA81H, lysosomal-associated membrane protein 3, LAMP-3
Protein in Homo sapiens
Protein · UniProt
CD63 antigen
- Gene
- CD63
- Organism
- Homo sapiens (Human)
- Length
- 238 aa
- Molecular mass
- 25,637 Da
- Evidence
- 1: Evidence at protein level
Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the …
Swiss-Prot (reviewed) · via UniProt
Research
761 papers- CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles.Blood · 2021
- Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution.Journal of extracellular vesicles · 2021
- Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations.Autophagy · 2022
- Basophil Degranulation Assay.Methods in molecular biology (Clifton, N.J.) · 2017
- Single Extracellular VEsicle Nanoscopy.Journal of extracellular vesicles · 2023
via PubMed
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- extracellular exosome
- molecular function
- protein binding
- found in taxon
- Homo sapiens
via Wikidata · CC0
Article · Deutsch
CD63 ist ein Oberflächenprotein aus der Gruppe der Tetraspanine. CD63 dient in der Medizin als Marker für die Aktivierung von Basophilen (ein Typ der Immunzellen) und wird zur Diagnose einer Immunglobulin-E-basierten Allergie verwendet (basophil activation test, BAT). Weiterhin wird es in der Biochemie zur Lokalisierung bestimmter Membranstrukturen (den multivesicular bodies) innerhalb von Zellen verwendet. Daneben dient es bei Blutplättchen (ein Typ Blutzellen) als Marker für eine erfolgte Aktivierung und Degranulation im Zuge einer Blutgerinnung. Ein Mangel an CD63 ist mit einer Form des Hermansky-Pudlak-Syndroms assoziiert.
Abstract from DBpedia / Wikipedia · CC BY-SA