CD74 molecule
Sign in to saveAlso known as CD74, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), Ii, gamma chain of class II antigens, HLA-DR-gamma, HLA-DR antigens-associated invariant chain, CD74 molecule, major histocompatibility complex, class II invariant chain, p33
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74. CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF).
~4 min read
Article
12 sectionsContents
- Function
- Clinical significance
- Vaccine adjuvant
- Cancer
- Axial spondyloarthritis
- Interactions
- Recovery functions
- History
- See also
- References
- Further reading
- External links
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74. CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF).
== Function == The nascent MHC class II protein in the rough endoplasmic reticulum (RER) binds a segment of the invariant chain (Ii; a trimer) in order to shape the peptide-binding groove and prevent the formation of a closed conformation.