CD74
Sign in to saveAlso known as CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), Ii, gamma chain of class II antigens, HLA-DR-gamma, HLA-DR antigens-associated invariant chain, CD74 molecule, major histocompatibility complex, class II invariant chain, p33
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74. CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF).
Protein · UniProt
HLA class II histocompatibility antigen gamma chain
- Gene
- CD74
- Organism
- Homo sapiens (Human)
- Length
- 296 aa
- Molecular mass
- 33,516 Da
- Evidence
- 1: Evidence at protein level
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- extracellular exosome
- exact match
- www.ncbi.nlm.nih.gov/protein/P04233
- found in taxon
- Homo sapiens
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