CD83 molecule
Sign in to saveAlso known as hCD83, B-cell activation protein, CD83, CD83 antigen (activated B lymphocytes, immunoglobulin superfamily), cell surface protein HB15, CD83 antigen, cell-surface glycoprotein
thumb|Dimeric CD83 extracellular domain structure CD83 (Cluster of Differentiation 83) is a human protein encoded by the gene.
Research
1,111 papers- The CD83 Molecule - An Important Immune Checkpoint.Frontiers in immunology · 2020
- CD83: a regulatory molecule of the immune system with great potential for therapeutic application.Journal of medical and dental sciences · 2006
- Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation.International journal of molecular sciences · 2022
- CD83 expressed by macrophages is an important immune checkpoint molecule for the resolution of inflammation.Frontiers in immunology · 2023
- CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation.Proceedings of the National Academy of Sciences of the United States of America · 2025
via PubMed
~6 min read
Article
13 sectionsContents
- Structure
- Gene
- Function
- Ligands
- Positive selection
- Regulatory T cells
- Dendritic cells
- B cells
- Hair Growth
- See also
- References
- Further reading
- External links
thumb|Dimeric CD83 extracellular domain structure CD83 (Cluster of Differentiation 83) is a human protein encoded by the gene.
== Structure == The membrane-bound form of CD83 consists of an extracellular V-type immunoglobulin-like domain, a transmembrane domain and a cytoplasmic signaling tail. A free soluble form consists of the immunoglobulin-like domain alone. Membrane-bound CD83 is expected to form trimers. Soluble CD83 is able to assemble into dodecameric complexes.