CDH4

Name

cadherin 4

Type

protein-coding

Position

61,252,208–61,940,617 (+)

Aliases

CAD4, R-CAD, RCAD

Ensembl

ENSG00000179242

RefSeq RNA

NM_001252338.2, NM_001252339.3, NM_001794.5, XM_047439812.1, XM_047439813.1

RefSeq protein

NP_001239267.1, NP_001239268.1, NP_001785.2, XP_047295768.1, XP_047295769.1

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

via MyGene.info

Gene · Ensembl

cadherin 4

Symbol

CDH4

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HSCHR20_1_CTG2:8,605-54,269

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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