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GeneQ18041567· pop 5· linked from 33 articles

CEP192

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Also known as PPP1R62, centrosomal protein 192

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.

Gene data

CEP192
Name
centrosomal protein 192
Type
protein-coding
Position
12,991,283–13,125,053 (+)
Aliases
PPP1R62
Ensembl
ENSG00000101639
RefSeq RNA
NM_018069.2, NM_032142.4, XM_005258107.4, XM_005258109.4, XM_006722326.4
RefSeq protein
NP_115518.3, XP_005258164.1, XP_005258166.1, XP_006722389.1, XP_006722390.1

Enables phosphatase binding activity. Involved in centrosome-templated microtubule nucleation; mitotic spindle assembly; and protein localization to centrosome. Located in centriole; centrosome; and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Pathways

Cell CycleOrganelle biogenesis and maintenanceRegulation of PLK1 Activity at G2/M TransitionLoss of Nlp from mitotic centrosomesRecruitment of mitotic centrosome proteins and complexesLoss of proteins required for interphase microtubule organization from the centrosomeCentrosome maturationRecruitment of NuMA to mitotic centrosomesMitotic G2-G2/M phasesCilium Assembly

via MyGene.info

Gene · Ensembl

centrosomal protein 192

Symbol
CEP192
Biotype
Protein coding
Organism
Homo sapiens
Location
18:12,991,283-13,125,053
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
73526
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/55125
genomic end
13125051
genomic start
12991361
chromosome
human chromosome 18
cytogenetic location
18p11.21
expressed in
sperm
Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections
Contents
  • References
  • External links
  • Further reading

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells. It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.

Excerpted from Wikipedia’s “CEP192” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0