CEP250
Sign in to saveAlso known as C-NAP1, CEP2, CNAP1, centrosomal protein 250, CRDHL2
Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.
Gene data
CEP250- Name
- centrosomal protein 250
- Type
- protein-coding
- Aliases
- C-NAP1, CEP2, CNAP1, CRDHL2
This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
via MyGene.info
Gene · Ensembl
centrosomal protein 250
- Symbol
- CEP250
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:35,455,131-35,519,280
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 38286
- exact match
- identifiers.org/ncbigene/11190
- found in taxon
- Homo sapiens
- genomic end
- 34099804
- genomic start
- 34042985
- chromosome
- human chromosome 20
- cytogenetic location
- 20q11.22
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.
==References==
Excerpted from Wikipedia’s “CEP250” article, available under the CC BY-SA 4.0 licence.