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GeneQ18036093· pop 6· linked from 36 articles

CNTRL

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Also known as CEP1, CEP110, FAN, bA165P4.1, centriolin

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.

Gene data

CNTRL
Name
centriolin
Type
protein-coding
Position
121,074,660–121,177,786 (+)
Aliases
CEP1, CEP110, FAN, bA165P4.1
Ensembl
ENSG00000119397
RefSeq RNA
NM_001330762.2, NM_001369892.1, NM_001369893.1, NM_001369894.1, NM_001369895.1
RefSeq protein
NP_001317691.1, NP_001356821.1, NP_001356822.1, NP_001356823.1, NP_001356824.1

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008].

Gene Ontology

Molecular function

protein binding

Pathways

Signaling by FGFR in diseaseCell CycleDiseaseSignaling by cytosolic FGFR1 fusion mutantsFGFR1 mutant receptor activationOrganelle biogenesis and maintenanceRegulation of PLK1 Activity at G2/M TransitionLoss of Nlp from mitotic centrosomesRecruitment of mitotic centrosome proteins and complexesLoss of proteins required for interphase microtubule organization from the centrosome

via MyGene.info

Gene · Ensembl

centriolin

Symbol
CNTRL
Biotype
Protein coding
Organism
Homo sapiens
Location
9:121,074,660-121,177,786
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
38260
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/11064
genomic end
121177729
genomic start
121074660
chromosome
human chromosome 9
cytogenetic location
9q33.2
expressed in
monocyte
Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections
Contents
  • References
  • External links
  • Further reading

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.

Excerpted from Wikipedia’s “CNTRL” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0