Structure via PubChem · Public domain (PubChem)
セスロマイシン
Sign in to saveAlso known as Abbott-195773, A-195773, ABT-773, Restanza
Cethromycin, trade name Restanza (initially known as ABT-773) is a ketolide antibiotic undergoing research for the treatment of community acquired pneumonia (CAP) and for the prevention of post-exposure inhalational anthrax, and was given an "orphan drug" status for this indication. Originally discovered and developed by Abbott, it was acquired by Advanced Life Sciences Inc. for further development.
Chemical data
- Formula
- C42H59N3O10
- Molecular weight
- 765.9 g/mol
- IUPAC name
- (1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-1,5,7,9,11,13-hexamethyl-9-[(E)-3-quinolin-3-ylprop-2-enoxy]-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- pneumonia
via ChEMBL · EBI
Research
148 papers- Cethromycin: a new ketolide antibiotic.The Annals of pharmacotherapy · 2013
- Cethromycin: A-195773, A-195773-0, A-1957730, Abbott-195773, ABT 773.Drugs in R&D · 2007
- Cethromycin: a promising new ketolide antibiotic for respiratory infections.Pharmacotherapy · 2010
- The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin.BMC microbiology · 2023
- Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections.Expert opinion on investigational drugs · 2008
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 765.420045
- Has use
- medication
Show 4 more facts
- chemical formula
- C₄₂H₅₉N₃O₁₀
- subject has role
- antibiotic
- canonical SMILES
- CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)C)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OCC=Cc4cc5ccccc5nc4)C)C)NC(=O)O2)C
- isomeric SMILES
- CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC\C=C\c4cc5ccccc5nc4)C)C)NC(=O)O2)C
Sources (2)
via Wikidata · CC0
Article · 日本語
セスロマイシン（Cethromycin）とは、マクロライド系の抗菌薬の中でもケトライドに分類される、抗菌薬の1種である。
Abstract from DBpedia / Wikipedia · CC BY-SA
Available in 8 languages
via Wikidata sitelinks · CC0