CFHR1

Also known as CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1

Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene.

Gene data

CFHR1

Name: complement factor H related 1
Type: protein-coding
Aliases: CFHL, CFHL1, CFHL1P, CFHR1P, FHL-1, FHR-1, FHR1, H36, H36-1, H36-2

This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009].

via MyGene.info