CFHR1
Sign in to saveAlso known as CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1
Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to CFHR1, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Vinony links it to 5 Wikipedia language editions.
Gene data
CFHR1- Name
- complement factor H related 1
- Type
- protein-coding
- Position
- 196,819,314–196,837,159 (+)
- Aliases
- CFHL, CFHL1, CFHL1P, CFHR1P, FHL-1, FHR-1, FHR1, H36, H36-1, H36-2
- Ensembl
- ENSG00000244414
- RefSeq RNA
- NM_001379306.1, NM_001379307.1, NM_001379308.1, NM_001379309.1, NM_001379310.1
- RefSeq protein
- NP_001366235.1, NP_001366236.1, NP_001366237.1, NP_001366238.1, NP_001366239.1
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
complement factor H related 1
- Symbol
- CFHR1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:196,819,314-196,837,159
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CFHR1 PDB 2bzm.png
Show 7 more facts
- HomoloGene ID
- 55632
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3078
- chromosome
- human chromosome 1
- genomic start
- 196788887
- genomic end
- 196801319
- cytogenetic location
- 1q31.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene.
==References==
Excerpted from Wikipedia’s “CFHR1” article, available under the CC BY-SA 4.0 licence.