CFLAR
Sign in to saveAlso known as CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called c-FLIP (FLICE-like inhibitory protein).
Gene data
CFLAR- Name
- CASP8 and FADD like apoptosis regulator
- Type
- protein-coding
- Position
- 201,116,154–201,176,687 (+)
- Aliases
- CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT
- Ensembl
- ENSG00000003402
- RefSeq RNA
- NM_001127183.4, NM_001127184.4, NM_001202515.1, NM_001202516.3, NM_001202517.3
- RefSeq protein
- NP_001120655.1, NP_001120656.1, NP_001189444.1, NP_001189445.1, NP_001189446.1
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CASP8 and FADD like apoptosis regulator
- Symbol
- CFLAR
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:201,116,005-201,176,687
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CFLAR PDB 3H11.png
Show 5 more facts
- HomoloGene ID
- 7652
- exact match
- identifiers.org/ncbigene/8837
- genomic end
- 202041410
- genomic start
- 201116154
- cytogenetic location
- 2q33.1
Sources (3)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- References
- Further reading
- External links
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called c-FLIP (FLICE-like inhibitory protein).
==References==
Available in 8 languages
via Wikidata sitelinks · CC0