File:Chlorpromazine.svg · Wikimedia Commons · See Wikimedia Commons
chlorpromazine
Sign in to saveAlso known as chlorpromazine HCl, Largactil®, Thorazine®, N-(3-dimethylaminopropyl)-3-chlorophenothiazine, 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine, 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine, CPZ
Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, severe behavioral problems in children including those with attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery, and hiccups that do not improve following other measures. It can be given orally (by mouth), by intramuscular injection (injection into a muscle), or intravenously (injection into a vein).
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 443519547
- Drug.image
- Chlorpromazine.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of chlorpromazine
- Drug.width
- 222
- Drug.image2
- Chlorpromazine-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of the chlorpromazine molecule
- Drug.tradename
- Thorazine, Largactil, others
- Drug.MedlinePlus
- a682040
- Drug.DailyMedID
- Chlorpromazine
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth, rectal, intramuscular, intravenous
- Drug.class
- Typical antipsychotic
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- AA01
- Drug.legal_AU
- S4
via Wikipedia infobox
Chemical data
- Formula
- C17H19ClN2S
- Molecular weight
- 318.9 g/mol
- IUPAC name
- 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
- SMILES
- CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
- InChIKey
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N
- XLogP
- 5.2
- Polar surface area
- 31.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
22,043 papers- Chlorpromazine versus placebo for schizophrenia.The Cochrane database of systematic reviews · 2000
- Chlorpromazine versus placebo for schizophrenia.The Cochrane database of systematic reviews · 2014
- Chlorpromazine versus placebo for schizophrenia.The Cochrane database of systematic reviews · 2003
- Chlorpromazine versus placebo for schizophrenia.The Cochrane database of systematic reviews · 2007
- Chlorpromazine's impact on Mytilus galloprovincialis: a multi-faceted investigation.Chemosphere · 2024
via PubMed
~27 min read
Encyclopedic overview
16 sectionsContents
- Medical uses
- Other uses
- Contraindications
- Adverse effects
- Discontinuation
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Society and culture
- In literature
- Names
- Research
- Veterinary use
- References
Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, severe behavioral problems in children including those with attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery, and hiccups that do not improve following other measures. It can be given orally (by mouth), by intramuscular injection (injection into a muscle), or intravenously (injection into a vein).
Chlorpromazine is in the typical antipsychotic class, and, chemically, is one of the phenothiazines. Its mechanism of action is not entirely clear but is believed to be related to its ability as a dopamine antagonist. It has antiserotonergic and antihistaminergic properties.
Excerpted from Wikipedia’s “chlorpromazine” article, available under the CC BY-SA 4.0 licence.