CLEC4M

Name

C-type lectin domain family 4 member M

Type

protein-coding

Position

7,763,031–7,769,606 (+)

Aliases

CD209L, CD209L1, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN

Ensembl

ENSG00000104938

RefSeq RNA

NM_001144904.2, NM_001144905.2, NM_001144906.2, NM_001144907.2, NM_001144908.2

RefSeq protein

NP_001138383.1, NP_001403298.1, NP_001403299.1, NP_055072.3

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. [provided by RefSeq, May 2020].

via MyGene.info

Gene · Ensembl

C-type lectin domain family 4 member M

Symbol

CLEC4M

Biotype

Protein coding

Organism

Homo sapiens

Location

19:7,763,031-7,769,606

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein CLEC4M PDB 1k9j.png

via Wikidata · CC0