مكون متمم 9

Also known as C9, complement component 9, complement component C9

بروتين في الإنسان العاقل

Protein · UniProt

Complement component C9

Gene: C9
Organism: Homo sapiens (Human)
Length: 559 aa
Molecular mass: 63,173 Da
Evidence: 1: Evidence at protein level

Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:39914456, PubMed:39814882, PubMed:9212048, PubMed:9634479). The comp…

3D-structureAge-related macular degenerationComplement alternate pathwayComplement pathwayCytolysisDirect protein sequencingDisease variantDisulfide bond

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Swiss-Prot (reviewed) · via UniProt

Research

2,062 papers

Complement.Annual review of biochemistry · 1975
Mapping of the Complement C9 Binding Region on Clonorchis sinensis Paramyosin.The Korean journal of parasitology · 2022
Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly.Nature communications · 2026
Reference typing report for complement components C6, C7 and C9 including mutations leading to deficiencies.Experimental and clinical immunogenetics · 1998
Terminal complement complexes with or without C9 potentiate antimicrobial activity against Neisseria gonorrhoeae.mBio · 2025

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Article · العربية

المكون المتمم 9، (بالإنجليزية: Complement component 9)‏، هو بروتين في جسم الإنسان يتم ترميزه بواسطة جين C9. هذا البروتين يشارك في النظام التكاملي الوقائي للجهاز المناعي في جسم الإنسان، الذي يستخدم لتحطيم نوع من الخلايا الحاملة للفيروسات. من خلال مشاركة كل من C5b,C6,C7,C8,C9 في تكوين . الأشخاص المصابين بنقص عنصر التكامل (9)، معرضين للإصابة، بأضرار الفيروسات البكتيرية أكثر من غيرهم.

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