Komplementkomponente C9
Sign in to saveAlso known as C9, complement component 9, complement component C9
Protein in Homo sapiens
Protein · UniProt
Complement component C9
- Gene
- C9
- Organism
- Homo sapiens (Human)
- Length
- 559 aa
- Molecular mass
- 63,173 Da
- Evidence
- 1: Evidence at protein level
Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:39914456, PubMed:39814882, PubMed:9212048, PubMed:9634479). The comp…
Swiss-Prot (reviewed) · via UniProt
Research
2,062 papers- Complement.Annual review of biochemistry · 1975
- Mapping of the Complement C9 Binding Region on Clonorchis sinensis Paramyosin.The Korean journal of parasitology · 2022
- Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly.Nature communications · 2026
- Reference typing report for complement components C6, C7 and C9 including mutations leading to deficiencies.Experimental and clinical immunogenetics · 1998
- Terminal complement complexes with or without C9 potentiate antimicrobial activity against Neisseria gonorrhoeae.mBio · 2025
via PubMed
Article · Deutsch
Die Komplementkomponente C9, auch als Komplementfaktor C9 bezeichnet, ist ein Protein des Komplementsystems und hat als Hauptbestandteil des Membranangriffskomplexes für das Immunsystem von Mensch und Tier eine wichtige Funktion. Mutationen im C9-Gen sind verantwortlich für seltene erbliche Anfälligkeit für Infektionen mit Neisseria.
Abstract from DBpedia / Wikipedia · CC BY-SA